| Expression pattern: |
UP |
| Associated gene: |
PIK3CD, p70S6K |
| Associated microRNA: |
miR-7 |
| Biological function: |
Up-regulated ciRS-7 expression is associated with deterioration of HCC and acts as an independent risk factor and predictive biomarker for hepatic MVI. |
| Molecular mechanism: |
ciRS-7 may promote hepatic MVI partly by sequestering miR-7 and disrupting the PIK3CD/p70S6K/mTOR pathway. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Western Blot; ROC Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
High ciRS-7 expression was correlated with hepatic MVI, AFP level and younger age; elevated ciRS-7 was an independent risk factor of MVI and showed predictive ability for MVI, but DFS difference was not statistically significant. |
| Description: |
This study found that ciRS-7 was not significantly different overall between paired HCC and non-tumor tissues, but elevated ciRS-7 in HCC was associated with MVI and other aggressive clinicopathological features. ciRS-7 was identified as an independent risk factor and potential predictive biomarker for hepatic MVI, possibly acting through miR-7 sequestration and disruption of the PIK3CD/p70S6K/mTOR pathway. |
| Confidence score: |
0.7081 |