circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: circBIRC6(2,3,4,5,6) / circBIRC6
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-468 / MDA-MB-468-RR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ITGB3, HNRNPL, Ago2
Associated microRNA: let-7 miRNAs, let-7a
Biological function: Acts (together with other ceRNA circRNAs) to promote ITGB3 mRNA stability in radioresistant TNBC.
Molecular mechanism: ceRNA mechanism: circBIRC6 sponges let-7 family miRNAs to promote ITGB3 mRNA stability (in tandem with circRAB12 and circBACE2).
Biological pathway or process:

ceRNA regulation (promotes); mRNA stability (promotes); migration (promotes)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; RIP (RNA Immunoprecipitation); Transfection; Bioinformatics Analysis
Clinical significance:

-
Description:

circBIRC6 is up-regulated in radioresistant TNBC cells and participates in an HNRNPL-driven ceRNA program that sponges let-7 miRNAs, contributing to increased ITGB3 mRNA stability and downstream pro-migratory behavior.
Confidence score:

0.5415
Other information
Title:

Resistance to radiation enhances metastasis by altering RNA metabolism.

Journal: Science advances
Published: 2025
PubMed ID: 41105760
Study type:

biological research
Data availability: -
Code availability: -