circRNA basic information
circBase ID: hsa_circ_0024224
Name: hsa_circ_ATM
Synonym: -
Host Gene: ATM
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005300
MONDO name: chronic kidney disease
Disease details: end-stage renal disease
Disease DO ID:
 784
Disease MeSH ID:
 D007676
Disease NCIt ID:
 C80078
Disease ICD11 ID:
 412389819
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: ATM
Associated microRNA: hsa-miR-7852-3p, hsa-miR-103a-2-5p, hsa-miR-6881-3p, hsa-miR-373-3p, hsa-miR-493-3p, hsa-miR-218-5p, hsa-miR-335-3p, hsa-miR-5003-3p, hsa-miR-125a-3p, hsa-miR-130b-5p, hsa-miR-149-5p, hsa-miR-301a-5p, hsa-miR-148b-3p, hsa-miR-362-5p, hsa-miR-6882-5p, hsa-miR-4659a-3p
Biological function: potential factor regulating platelet autophagy in MHD via interaction with autophagy-regulated miRNAs (predicted ceRNA component)
Molecular mechanism: ceRNA mechanism (high competitive interaction with miRNAs; predicted targeting of ATM)
Biological pathway or process:

autophagy (other); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsacirc0024224 (ATM-associated) was highlighted as a key circRNA node in the predicted platelet autophagy ceRNA network in MHD, showing high competitive interaction with multiple miRNAs and potentially regulating autophagy via ATM. The evidence is based on RNA-seq differential expression and in-silico network predictions without experimental validation.
Confidence score:

0.1768
Other information
Title:

Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets.

Journal: Medicine
Published: 2025
PubMed ID: 41088574
Study type:

combined biological and clinical study
Data availability: -
Code availability: -