circRNA basic information
circBase ID: hsa_circ_0089788
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chrX:1505044-1508620:-
Genomic location(hg38): chrX:1386151-1389727:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005300
MONDO name: chronic kidney disease
Disease details: end-stage renal disease
Disease DO ID:
 784
Disease MeSH ID:
 D007676
Disease NCIt ID:
 C80078
Disease ICD11 ID:
 412389819
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: VEGFA, FOXO3, CXCR4, CASP8
Associated microRNA: hsa-miR-1321, hsa-miR-185-5p, hsa-miR-214-3p, hsa-miR-217, hsa-miR-218-5p, hsa-miR-2682-5p, hsa-miR-3179, hsa-miR-331-3p, hsa-miR-34b-5p, hsa-miR-4306, hsa-miR-449c-5p, hsa-miR-4644, hsa-miR-4739, hsa-miR-4756-5p, hsa-miR-665, hsa-miR-122-5p, hsa-miR-2467-3p, hsa-miR-296-5p, hsa-miR-326, hsa-miR-330-5p, hsa-miR-378a-3p, hsa-miR-3918, hsa-miR-422a, hsa-miR-4640-5p, hsa-miR-491-5p, hsa-miR-518d-5p, hsa-miR-519b-5p, hsa-miR-519c-5p, hsa-miR-642b-5p, hsa-miR-3619-5p, hsa-miR-518e-5p, hsa-miR-518f-5p, hsa-miR-519a-5p, hsa-miR-520c-5p, hsa-miR-522-5p, hsa-miR-523-5p, hsa-miR-526a, hsa-miR-761
Biological function: potential regulator of platelet autophagy-related mRNAs (ceRNA component) in MHD
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA network predicted) related to autophagy in platelets
Biological pathway or process:

autophagy (other); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0089788 was identified by platelet RNA-seq as a circRNA included in a predicted autophagy-related ceRNA network in MHD, potentially regulating key autophagy-associated mRNAs (e.g., VEGFA, FOXO3, CXCR4, CASP8) through miRNA competition. No experimental validation beyond sequencing/prediction was reported.
Confidence score:

0.1768
Other information
Title:

Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets.

Journal: Medicine
Published: 2025
PubMed ID: 41088574
Study type:

combined biological and clinical study
Data availability: -
Code availability: -