| Expression pattern: |
DN |
| Associated gene: |
Foxo3 |
| Associated microRNA: |
- |
| Biological function: |
Potentially promotes apoptosis and is associated with better prognosis in AML (expression is decreased in AML). |
| Molecular mechanism: |
Proposed ceRNA competition with Foxo3 for miRNA binding, potentially affecting Foxo3 expression (not experimentally validated in this study). |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ-Foxo3 could differentiate AML patients from control people with an AUC of 0.633; circ-Foxo3 expression was not significantly correlated with OS in this cohort. |
| Description: |
circ-Foxo3 is down-regulated in de novo AML bone marrow samples compared with controls. It shows diagnostic potential by ROC analysis, while its association with overall survival is not statistically significant in this cohort; higher circ-Foxo3 shows a non-significant trend toward longer survival. The paper discusses a possible relationship with the host gene Foxo3 and a speculative miRNA-related mechanism, but miRNA partners were not identified in this study. |
| Confidence score: |
0.5121 |