circRNA basic information
circBase ID: hsa_circ_0003154
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:134076752-134079742:+
Genomic location(hg38): chr5:134741062-134744052:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CLPTM1L, GSTM1
Associated microRNA: hsa-miR-1260b
Biological function: carcinogenic potential
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA network)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003154 is down-regulated in TERT promoter-mutant HCC and is placed in a circRNA-miRNA-mRNA ceRNA network, where reduced hsa_circ_0003154 may relieve repression of hsa-miR-1260b, associated with lower CLPTM1L and GSTM1 in the constructed axis. This axis is proposed to have carcinogenic potential in the context of TERT promoter mutations.
Confidence score:

0.1768
Other information
Title:

Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations.

Journal: Journal of hepatocellular carcinoma
Published: 2022
PubMed ID: 36471741
Study type:

combined biological and clinical study
Data availability: Sequence Read Archive (SRA) PRJNA808183
Code availability: -