| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-136-5p, hsa-miR-100-3p, hsa-miR-144-5p, hsa-miR-149-5p, hsa-miR-214-5p |
| Biological function: |
Promotes OSCC cell viability, migration and invasion; inhibits apoptosis. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which hsa_circ_0000831 may sponge five miRNAs and affect downstream target genes enriched in cancer-related pathways (bioinformatics prediction; not experimentally validated). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
High diagnostic performance for OSCC based on ROC curve analysis (AUC large). |
| Description: |
hsa_circ_0000831 (from CEP192) is upregulated in OSCC tissues and shows diagnostic potential by ROC analysis. Functionally, its knockdown suppresses OSCC cell viability/migration/invasion and increases apoptosis, while a ceRNA network with five predicted miRNAs is proposed but not experimentally validated. |
| Confidence score: |
0.6758 |