circRNA basic information
circBase ID: -
Name: mmu_circ_FoxO3
Synonym: circular RNA FoxO3
Host Gene: FoxO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

brain; cortical tissue; cortical brain tissues; brain cortex
Cell lines:

bEnd.3
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: FoxO3, HuR, ubiquitin ligases, ribosomal subunits
Associated microRNA: miR-22, miR-543, miR-433
Biological function: Alleviates APOE4-induced brain damage, reduces p-tau and Abeta aggregation, promotes autophagy, and facilitates clearance of neurotoxic protein aggregates.
Molecular mechanism: circ-FoxO3 upregulates its parental gene FoxO3, activates autophagy, and enhances clearance of pathogenic p-tau and Abeta protein aggregates.
Biological pathway or process:

autophagy (promotes); other pathway/process (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; IF (Immunofluorescence); Transfection; In Vivo Animal Model; Western Blot
Clinical significance:

Potential therapeutic target for mitigating APOE4-related neuropathology.
Description:

circ-FoxO3 is downregulated in the brains of APOE4 transgenic mice with AD-like neuropathology. Its overexpression reduces p-tau and Abeta accumulation, whereas knockdown worsens these aggregates. Mechanistically, circ-FoxO3 promotes FoxO3-mediated autophagy, suggesting therapeutic potential for APOE4-related neurodegenerative pathology.
Confidence score:

0.414
Other information
Title:

Circ-FoxO3 alleviates APOE4-induced brain pathology through FoxO3-mediated autophagy.

Journal: Molecular genetics and genomics : MGG
Published: 2026
PubMed ID: 41653210
Study type:

biological research
Data availability: The data that support the findings of this study are included in this published article and its additional material.
Code availability: -