circRNA basic information
circBase ID: -
Name: hsa_circ_LINC00632
Synonym: ciRS-7 / CDR1as
Host Gene: LINC00632
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004970
MONDO name: adenocarcinoma
Disease details: adenocarcinoma
Disease DO ID:
 299
Disease MeSH ID:
 D000230
Disease NCIt ID:
 C2852
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

FFPE adenocarcinoma tissue samples; full tissue sections; tissue microarrays (TMAs); laser-capture microdissected colon adenocarcinoma tissues
Cell lines:

Caco-2; HCT116; TFK-1; EGI-1; SKOV-3; CAOV3; Hec-1-a; KLE; SNU-1; 23132/87; A459; H1650; H1975; LNCaP; DU145; MDA-MB-231; PaTu-8898T; CCD18-Co
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: miR-7
Biological function: Epigenetically regulated expression; mainly expressed in tumor microenvironment rather than cancer cells across adenocarcinomas.
Molecular mechanism: Epigenetic regulation of ciRS-7 expression via DNA methylation and histone acetylation (H3K9Ac) at the LINC00632 T3 promoter; H3K27me3 negligible; ciRS-7 has many miR-7 binding sites.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
H
M
Validation methods:

RT-qPCR; ISH (In Situ Hybridization); Microarray; Clinical Sample Validation; MSP (Methylation-Specific PCR); ChIP / ChIP-seq; Transfection
Clinical significance:

-
Description:

This study shows that ciRS-7 (CDR1as) is largely absent from adenocarcinoma cancer cells but present in stromal/TME compartments, with exceptions such as many breast tumor specimens. Its expression is epigenetically regulated, primarily through DNA methylation and H3K9 acetylation at the LINC00632 T3 promoter, and can be reactivated in vitro using demethylating and HDAC-inhibitor treatments.
Confidence score:

0.6428
Other information
Title:

ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas.

Journal: PLoS genetics
Published: 2025
PubMed ID: 40455824
Study type:

combined biological and clinical study
Data availability: S1 File; S2 File
Code availability: -