| Expression pattern: |
UP |
| Associated gene: |
MAPK10 |
| Associated microRNA: |
- |
| Biological function: |
circ_0000515 promotes HCC cell proliferation, migration, tumor growth and malignant progression; knockdown of circ_0000515 attenuates proliferative and migratory abilities. |
| Molecular mechanism: |
circ_0000515 binds MAPK10 and negatively regulates MAPK10, thereby promoting HCC proliferation, migration and tumorigenicity. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000515 expression predicts advanced tumor staging, lymphatic metastasis, poor progression-free survival, low overall survival, and has diagnostic and prognostic value in HCC. |
| Description: |
circ_0000515 is upregulated in HCC tissues and cell lines and high expression is associated with advanced stage, lymphatic metastasis, and poor survival. Functionally, circ_0000515 promotes HCC cell proliferation, migration and xenograft tumor growth. Mechanistically, it binds and negatively regulates MAPK10, contributing to malignant HCC progression. |
| Confidence score: |
0.7396 |