circRNA basic information
circBase ID: -
Name: hsa_circ_PSMC3
Synonym: Circ PSMC3 / Circular PSMC3
Host Gene: PSMC3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; para-cancer tissues; adjacent normal tissues; tumor tissues
Cell lines:

PC3; DU145; LN-Cap; LNCap; P69
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: DGCR8
Associated microRNA: -
Biological function: Suppresses PCa cell proliferation, migration and invasion; regulates cell cycle by promoting G0/G1 arrest; decreases tumor formation in vivo.
Molecular mechanism: circPSMC3 inhibits PCa growth by downregulating DGCR8; DGCR8 expression was negatively correlated with circPSMC3 expression in PCa tissues.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (other); metastasis (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Western Blot; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Survival Analysis
Clinical significance:

Low circPSMC3 expression was associated with worse disease-free survival and poor prognosis of PCa patients; circPSMC3 may be a prospective target for PCa therapy.
Description:

circPSMC3 is downregulated in prostate cancer tissues and cell lines, and low expression is associated with worse disease-free survival. Functionally, circPSMC3 acts as a tumor suppressor by inhibiting PCa cell proliferation, migration and invasion, regulating cell cycle arrest, and reducing xenograft tumor formation. Mechanistically, the study links circPSMC3 to DGCR8 downregulation and suggests circPSMC3 as a potential therapeutic target.
Confidence score:

0.622
Other information
Title:

Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32196577
Study type:

combined biological and clinical study
Data availability: -
Code availability: -