circRNA basic information
circBase ID: hsa_circ_0001222
Name: hsa_circ_FBXO7
Synonym: circFBXO7
Host Gene: FBXO7
Genomic location(hg19): chr22:32874967-32881196:+
Genomic location(hg38): chr22:32478980-32485209:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005527
MONDO name: toxic encephalopathy
Disease details: arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity
Disease DO ID:
 3602
Disease MeSH ID:
 D020258
Disease NCIt ID:
 C27961
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SH-SY5Y
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Bioinformatics-predicted miRNA interaction network (not experimentally validated).
Biological pathway or process:

Wnt/beta-catenin (unclear); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circFBXO7 is up-regulated in arsenic-exposed differentiated SH-SY5Y cells and appears in predicted circRNA-miRNA networks; discussion links it to Wnt/beta-catenin signaling in other contexts but no mechanistic validation was performed here.
Confidence score:

0.1768
Other information
Title:

Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity.

Journal: BMC genomics
Published: 2025
PubMed ID: 40999364
Study type:

biological research
Data availability: GSE278489
Code availability: -