| Expression pattern: |
UP |
| Associated gene: |
SERPINB5, MMP11, Akt, CREB |
| Associated microRNA: |
miR4516, miR1227-5p |
| Biological function: |
Acts as a tumor promoter and proliferative factor in gastric cancer; promotes gastric cancer progression by functioning as a ceRNA for miR4516 and miR1227-5p and stimulating SERPINB5 and MMP11 expression; may affect Akt/CREB signaling pathway activation. |
| Molecular mechanism: |
ceRNA mechanism: circRNA0047905 sponges miR4516 and miR1227-5p, relieving miRNA-mediated suppression of SERPINB5 and MMP11; circRNA0047905 down-regulation inhibits Akt/CREB signaling pathway activation. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot |
| Clinical significance: |
circRNA0047905 may serve as a biomarker and promising target for gastric cancer diagnosis and therapy. |
| Description: |
circRNA0047905 is up-regulated in gastric cancer and functions as a tumor-promoting circRNA. It acts as a ceRNA for miR4516 and miR1227-5p to increase SERPINB5 and MMP11 expression, and its down-regulation suppresses Akt/CREB signaling activation. The study suggests circRNA0047905 may be a proliferative factor and potential biomarker or therapeutic target for gastric cancer. |
| Confidence score: |
0.659 |