| Expression pattern: |
UP |
| Associated gene: |
ARL2 |
| Associated microRNA: |
miR-541-3p |
| Biological function: |
promotes radio-resistance, proliferation, tube formation, migration, invasion and tumor growth; inhibits apoptosis in cervical cancer |
| Molecular mechanism: |
circ_0085616 acts as a miRNA sponge for miR-541-3p and positively regulates ARL2 expression through the miR-541-3p/ARL2 axis |
| Biological pathway or process: |
radioresistance (promotes); proliferation (promotes); apoptosis (inhibits); angiogenesis (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Tube Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
provided novel potential targets for cervical cancer treatment |
| Description: |
circ_0085616 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes radio-resistance, proliferation, angiogenesis, migration, invasion and tumor growth while suppressing apoptosis, mainly by sponging miR-541-3p to increase ARL2 signaling. |
| Confidence score: |
0.7375 |