circRNA basic information
circBase ID: hsa_circ_0001699
Name: hsa_circ_CDK13
Synonym: circCDK13
Host Gene: CDK13
Genomic location(hg19): chr7:40027197-40041630:+
Genomic location(hg38): chr7:39987598-40002031:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver cancer tissues; hepatocellular carcinoma tissues; human cancerous liver tissues; adjacent tissues
Cell lines:

HepG2; Huh7; SK-Hep1; MHCC97-H; MHCC97-L; SMCC7721; L-02; MHCC-LM3; SK-Hep-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circCDK13 suppresses liver cancer cell proliferation, migration, invasion, cell cycle progression, and tumorigenesis.
Molecular mechanism: circCDK13 overexpression regulates downstream gene expression and suppresses JAK/STAT and PI3K/AKT signaling, including downregulation of phosphorylated AKT and phosphorylated STAT3.
Biological pathway or process:

JAK/STAT (inhibits); PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; Cell Cycle Assay; Transwell Assay; Microarray; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circCDK13 may be explored as a biomarker for liver cancer diagnosis and treatment.
Description:

circCDK13 (hsa_circ_0001699), derived from the human CDK13 gene, is down-regulated in liver cancer cell lines and hepatocellular carcinoma tissues. Functional overexpression experiments show that circCDK13 suppresses liver cancer cell proliferation, migration, invasion, cell cycle progression, and xenograft tumor growth. Mechanistically, its tumor-suppressive effects are associated with inhibition of JAK/STAT and PI3K/AKT signaling, including decreased phosphorylated STAT3 and AKT.
Confidence score:

0.7283
Other information
Title:

Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer.

Journal: International journal of oncology
Published: 2018
PubMed ID: 29658568
Study type:

combined biological and clinical study
Data availability: The analyzed datasets generated during the study are available from the corresponding author on reasonable request.
Code availability: -