| Expression pattern: |
UP |
| Associated gene: |
EIF4A3, c-MYC |
| Associated microRNA: |
- |
| Biological function: |
Enhances RCC cell proliferation, migration, invasion and promotes lung metastasis/tumor growth. |
| Molecular mechanism: |
CircPVT1 binds EIF4A3 to facilitate c-MYC expression; additionally circPVT1 encodes cP104aa which promotes c-MYC upregulation via protein interactions. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); mRNA stability (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; H&E Staining; Survival Analysis; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP |
| Clinical significance: |
High circPVT1 expression is associated with poor prognosis in RCC; correlated with Fuhrman grade. |
| Description: |
circPVT1 is up-regulated in RCC and associated with poor prognosis. It promotes RCC proliferation, invasion/migration, EMT and lung metastasis. Mechanistically, circPVT1 binds EIF4A3 to increase c-MYC expression and also contributes via encoding cP104aa. |
| Confidence score: |
0.8913 |