| Expression pattern: |
UP |
| Associated gene: |
BRCA1 |
| Associated microRNA: |
hsa-miR-1287-5p, hsa-miR-1343-3p, hsa-miR-148b-5p, hsa-miR-181a-3p, hsa-miR-191-5p, hsa-miR-193b-3p, hsa-miR-330-5p, hsa-miR-582-3p, hsa-miR-92b-3p, hsa-miR-24-3p |
| Biological function: |
May influence the pathophysiological processes of psychological distress in NPC patients receiving radiotherapy. |
| Molecular mechanism: |
Putative ceRNA mechanism via hsa-miR-24-3p and hsa-miR-92b-3p regulating BRCA1 within a constructed ceRNA network. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Significant expression differences between rise and decline distress groups during radiotherapy (potential genetic factor for PD trajectories). |
| Description: |
hsa_circ_0004277 is higher in the rise-distress trajectory than in the decline-distress trajectory in NPC patients during radiotherapy (blood/ PBMC samples). The study proposes a ceRNA mechanism involving hsa-miR-24-3p or hsa-miR-92b-3p regulating BRCA1, potentially contributing to PD-related pathophysiology. |
| Confidence score: |
0.4032 |