| Expression pattern: |
UP |
| Associated gene: |
HMGB2 |
| Associated microRNA: |
miR-543 |
| Biological function: |
Promotes cervical cancer cell viability/proliferation and EMT, and inhibits apoptosis (oncogenic role). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-543, thereby modulating the miR-543 target HMGB2. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May provide a prognostic biomarker and molecular therapeutic target for cervical cancer. |
| Description: |
circRNA THBS1 is upregulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-543 to relieve repression of HMGB2, thereby promoting viability/proliferation and EMT while inhibiting apoptosis in cervical cancer cells. |
| Confidence score: |
0.6479 |