| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Promotes cisplatin (DDP) resistance; promotes proliferation/colony formation; modulates apoptosis in DDP-resistant NSCLC cells. |
| Molecular mechanism: |
Alters cisplatin response by regulating proliferation and apoptosis; specific downstream miRNA/mRNA axis not identified in this study. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (other); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; divergent primers PCR; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0006006 is associated with worse survival prognosis in NSCLC and has diagnostic efficacy for NSCLC and DDP resistance (ROC AUC=0.91 for NSCLC; 0.80 for DDP-resistant vs DDP-sensitive). |
| Description: |
hsa_circ_0006006 is up-regulated in NSCLC and further elevated in cisplatin (DDP)-resistant settings (patients’ serum and A549/DDP cells). Functional assays show that hsa_circ_0006006 promotes DDP resistance by enhancing colony formation/proliferation and modulating apoptosis. Clinically, high hsa_circ_0006006 correlates with poor survival and shows diagnostic potential for NSCLC and DDP resistance. |
| Confidence score: |
0.8141 |