| Expression pattern: |
UP |
| Associated gene: |
YAP, TAZ |
| Associated microRNA: |
miR-9-3p |
| Biological function: |
promotes HCC cell proliferation, migration, invasion/metastasis, and tumor growth |
| Molecular mechanism: |
acts as a miR-9-3p sponge to upregulate YAP/TAZ and activate Hippo signaling output |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
potential therapeutic target; prognostic indicators (proposed) |
| Description: |
HBV-circRNA-5 is a virus-encoded circRNA detected in HBV-positive HCC tissues/cells and mainly localized in the cytoplasm. It promotes HCC proliferation and metastatic phenotypes and enhances tumor growth in vivo, largely by sponging miR-9-3p to increase YAP/TAZ and activate Hippo/YAP output. |
| Confidence score: |
0.7927 |