circRNA basic information
circBase ID: -
Name: hsa_circ_SATB2
Synonym: circSATB2
Host Gene: SATB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

human whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker in human whole blood; elevated circSATB2 levels distinguish lung cancer patients from healthy individuals.
Molecular mechanism: Not a disease molecular mechanism study; circSATB2 is detected using a polarity-switchable PEC biosensor with TWJ-Exo III signal cyclic amplification.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circSATB2 level in human whole blood can effectively distinguish lung cancer patients from healthy individuals; machine-learning-assisted diagnosis achieved 100% accuracy, sensitivity and specificity.
Description:

This study developed a renewable polarity-switchable PEC biosensor to quantify circSATB2 in human whole blood. circSATB2 was significantly higher in lung cancer patients than in healthy individuals, and its measured level supported machine-learning-based intelligent diagnosis of lung cancer.
Confidence score:

0.459
Other information
Title:

Machine learning-assisted renewable and polarity-switchable photoelectrochemical biosensor for circRNA intelligent diagnosis.

Journal: Biosensors & bioelectronics
Published: 2026
PubMed ID: 41187355
Study type:

combined biosensor development and clinical diagnostic study
Data availability: No data was used for the research described in the article; Supplementary data to this article can be found online at https://doi. org/10.1016/j.bios.2025.118197.
Code availability: -