| Expression pattern: |
DN |
| Associated gene: |
SHIP1, VE-cadherin, TLR4, NLRP3, ASC1, caspase-1, GSDMD, IL-1beta, IL-18 |
| Associated microRNA: |
miR-155-5p |
| Biological function: |
Inhibits macrophage pyroptosis and inflammation; protects endothelial cell integrity by promoting VE-cadherin expression via reducing IL-1beta and IL-18 release. |
| Molecular mechanism: |
Acts as a ceRNA (molecular sponge) for miR-155-5p to upregulate SHIP1, thereby suppressing TLR4/NLRP3 inflammasome activation and downstream pyroptosis-associated cytokines. |
| Biological pathway or process: |
pyroptosis (inhibits); inflammation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic and therapeutic target for pneumonia-induced sepsis. |
| Description: |
circ_0075723 is down-regulated in plasma/CD14+ monocytes from pneumonia-induced sepsis patients. It suppresses macrophage pyroptosis and inflammatory cytokine release by sponging miR-155-5p to increase SHIP1 expression, which in turn dampens TLR4/NLRP3 inflammasome activation and helps preserve endothelial integrity via VE-cadherin. |
| Confidence score: |
0.8335 |