| Expression pattern: |
UP |
| Associated gene: |
SLC7A14, KLHL30 |
| Associated microRNA: |
hsa-mir-4695-3p, hsa-mir-7847-3p |
| Biological function: |
May contribute to the pathogenesis of fatigue-type diabetes by regulating glucose transport, mitochondrial energy metabolism, and insulin signaling via a ceRNA network. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0078539 sponges hsa-mir-4695-3p to relieve inhibition of SLC7A14. |
| Biological pathway or process: |
ceRNA regulation (promotes); mitochondrial function (other); PI3K/AKT (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Detecting the expression levels of SLC7A14 and their related circular RNAs in blood or tissue samples can help distinguish between ordinary T2DM and the F-T2DM subtype. |
| Description: |
hsa_circ_0078539 is up-regulated in F-T2DM and participates in an up-regulated ceRNA network. It likely acts as a miRNA sponge (e.g., hsa-mir-4695-3p) to de-repress SLC7A14, linking to altered energy metabolism and insulin signaling relevant to fatigue-type diabetes. |
| Confidence score: |
0.5922 |