| Expression pattern: |
UP |
| Associated gene: |
ADAM9 |
| Associated microRNA: |
miR-488-3p |
| Biological function: |
Promotes NSCLC cell growth, proliferation, migration, invasion and metastatic properties, and decreases apoptosis; high expression is associated with lymph node metastasis, advanced TNM stage and adverse prognosis. |
| Molecular mechanism: |
circ_0020123 acts as a ceRNA by sponging miR-488-3p/miR-488e3p, thereby relieving miR-488-3p-mediated inhibition of ADAM9 and increasing ADAM9 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0020123 expression correlates with positive lymph node metastasis, advanced TNM stages, shorter overall survival, and independent prognostic value in NSCLC patients; circ_0020123 may be a target for NSCLC prognosis prediction and therapy. |
| Description: |
circ_0020123 is up-regulated in NSCLC tissues and cell lines and is associated with advanced clinicopathological features and poor overall survival. Functionally, it promotes NSCLC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0020123 acts as a ceRNA for miR-488-3p/miR-488e3p to upregulate ADAM9, contributing to NSCLC progression. |
| Confidence score: |
0.7396 |