circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: circNRIP1 / exo_circ_38881
Host Gene: NRIP1
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma / ESCC
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

KYSE-150; TE-10; MRC5
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRMT6
Associated microRNA: -
Biological function: Activates CAFs and promotes ESCC cell migration and invasion.
Molecular mechanism: Exosomal circNRIP1 activates CAFs by binding the m1A methyltransferase TRMT6 in a TRMT6-dependent manner, leading to increased inflammatory cytokines and ECM-related markers, which enhances ESCC cell migration/invasion.
Biological pathway or process:

migration (promotes); invasion (promotes); inflammation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Transfection; Transwell Assay; ELISA; Western Blot
Clinical significance:

-
Description:

In ESCC, hypoxia increases circNRIP1 enrichment in tumor-cell-derived exosomes. Exosomal circNRIP1 is transferred into fibroblasts to activate a CAF-like phenotype and consequently promotes ESCC cell migration and invasion, mainly through binding and functionally depending on TRMT6.
Confidence score:

0.7754
Other information
Title:

Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.

Journal: BMC gastroenterology
Published: 2025
PubMed ID: 40836210
Study type:

combined biological and clinical study
Data availability: 10.1186/s12876-025-03978-w; exoRBaseV2 (http://www.exoRBase.org)
Code availability: -