| Expression pattern: |
UP |
| Associated gene: |
FOXK2, Ago2 |
| Associated microRNA: |
miR-96-5p |
| Biological function: |
Promotes angiogenesis and CNV progression by enhancing endothelial viability/proliferation, migration, and tube formation, and inhibiting apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-96-5p, thereby increasing FOXK2 expression. |
| Biological pathway or process: |
angiogenesis (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Tube Formation Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circ-MALAT1 is increased in aqueous humor (AH) of nAMD patients versus age-related cataract (ARC), while not significantly different in plasma. |
| Description: |
In CNV/nAMD models, circ-MALAT1 is up-regulated and promotes pathological angiogenesis. It functions as a ceRNA that sponges miR-96-5p to increase FOXK2, thereby enhancing endothelial cell viability/proliferation, migration and tube formation and reducing apoptosis. circ-MALAT1 is also elevated in aqueous humor from nAMD patients, supporting potential translational relevance. |
| Confidence score: |
0.8149 |