circRNA basic information
circBase ID: hsa_circ_0001490
Name: hsa_circ_KIF2A
Synonym: hsacirc0001490
Host Gene: KIF2A
Genomic location(hg19): chr5:61653517-61657356:+
Genomic location(hg38): chr5:62357690-62361529:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006955
MONDO name: rheumatic heart disease
Disease details: rheumatic heart disease / RHD
Disease DO ID:
 0050827
Disease MeSH ID:
 D012214
Disease NCIt ID:
 C34882
Disease ICD11 ID:
 291726710
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MED17, MED22, MED6, MED29, CDK8, MED8, CDK19, PPARGC1B, MED20, THRAP3
Associated microRNA: hsa-miR-5003-5p, hsa-miR-659-3p, hsa-miR-330-3p, hsa-miR-8077, hsa-miR-622, hsa-miR-329-5p, hsa-miR-145-5p, hsa-miR-346, hsa-miR-937-5p, hsa-miR-3978, hsa-miR-4436b-5p
Biological function: Potential diagnostic biomarker for RHD; may influence RHD occurrence and development via a predicted ceRNA network.
Molecular mechanism: Predicted competing endogenous RNA (ceRNA) mechanism via circRNA-miRNA-mRNA/hub gene regulatory network.
Biological pathway or process:

Wnt/beta-catenin (other); MAPK (other); TGF-beta/SMAD (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC analysis revealed hsa_circ_0001490 had an AUC of 0.792 (95% CI: 0.69-0.89; sensitivity: 93.5%; specificity: 67.4%) for predicting RHD.
Description:

hsa_circ_0001490 is up-regulated in RHD patient plasma and shows diagnostic value by ROC analysis. Bioinformatic ceRNA network prediction links it to multiple miRNAs and hub genes (e.g., MED17/CDK8), with enrichment in Wnt, MAPK and TGF-beta/SMAD-related terms, suggesting potential involvement in RHD pathogenesis.
Confidence score:

0.5047
Other information
Title:

Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker.

Journal: Frontiers in cardiovascular medicine
Published: 2025
PubMed ID: 40822008
Study type:

combined biological and clinical study
Data availability: GSE168932
Code availability: -