circRNA basic information
circBase ID: hsa_circ_0003563
Name: hsa_circ_PPP2R5C
Synonym: -
Host Gene: PPP2R5C
Genomic location(hg19): chr6:45399599-45405788:+
Genomic location(hg38): chr6:45431862-45438051:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007915
MONDO name: systemic lupus erythematosus
Disease details: systemic lupus erythematosus / SLE
Disease DO ID:
 9074
Disease MeSH ID:
 D008180
Disease NCIt ID:
 C3201
Disease ICD11 ID:
 749596428
Disease OMIM ID:
 152700
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Candidate biomarker for distinguishing moderate vs severe SLE severity (identified among top differentially expressed circRNAs).
Molecular mechanism: Not specified (no experimental validation beyond RNA-seq and statistical analyses).
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; ROC Analysis; Bioinformatics Analysis
Clinical significance:

All identified circRNAs had significant diagnostic value for distinguishing moderate and severe SLE severity by ROC analysis (group-level statement).
Description:

hsa_circ_0003563 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.
Confidence score:

0.348
Other information
Title:

Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.

Journal: Frontiers in immunology
Published: 2025
PubMed ID: 40821807
Study type:

combined biological and clinical study
Data availability: PRJNA1295701
Code availability: -