circRNA basic information
circBase ID: hsa_circ_0003288
Name: hsa_circ_BIRC6
Synonym: circ-BIRC6
Host Gene: BIRC6
Genomic location(hg19): chr2:32703702-32718734:+
Genomic location(hg38): chr2:32478634-32493667:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues; tumor tissues (xenograft)
Cell lines:

Huh-7; Hep3B; THLE-2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: YWHAZ
Associated microRNA: miR-877-5p
Biological function: promotes HCC tumorigenesis (supports proliferation and inhibits apoptosis); mediates paclitaxel suppressive effects when down-regulated
Molecular mechanism: circ-BIRC6 acts as a ceRNA (molecular sponge) for miR-877-5p to regulate YWHAZ expression; paclitaxel inhibits circ-BIRC6 leading to increased miR-877-5p and decreased YWHAZ
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

circ-BIRC6 is upregulated in HCC tissues/cells and promotes tumorigenesis by sponging miR-877-5p to increase YWHAZ expression. Paclitaxel suppresses HCC partly by downregulating circ-BIRC6, thereby relieving miR-877-5p suppression and reducing YWHAZ.
Confidence score:

0.6536
Other information
Title:

Paclitaxel Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating Circ-BIRC6/miR-877-5p/YWHAZ Axis.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 33061425
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -