| Expression pattern: |
UP |
| Associated gene: |
placental growth factor (PGF) gene, PGF, mTOR, p70 S6k |
| Associated microRNA: |
miR-335-5p |
| Biological function: |
CircRNA Uxs1 promotes choroidal neovascularization and angiogenic endothelial cell functions including tube formation, migration, and proliferation; its knockdown suppresses endothelial cell angiogenic activity and alleviates CNV lesions in vivo. |
| Molecular mechanism: |
CircRNA Uxs1 acts as a miR-335-5p sponge, increases PGF expression, and activates the mTOR/p70 S6k pathway. |
| Biological pathway or process: |
angiogenesis (promotes); proliferation (promotes); migration (promotes); ceRNA regulation (promotes); PI3K/AKT/mTOR (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Tube Formation Assay; In Vivo Animal Model; IF (Immunofluorescence); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircRNA Uxs1 is upregulated in CNV patient specimens and may serve as a promising therapeutic target for CNV. |
| Description: |
CircRNA Uxs1 is upregulated in CNV patient samples and laser-induced CNV mouse models. It promotes CNV-associated angiogenesis, endothelial proliferation, and migration by sponging miR-335-5p, thereby increasing PGF expression and activating the mTOR/p70 S6k pathway. Knockdown of circRNA Uxs1 suppresses endothelial angiogenic functions and reduces CNV lesions, supporting its potential as a therapeutic target. |
| Confidence score: |
0.7938 |