circRNA basic information
circBase ID: hsa_circ_0001563
Name: hsa_circ_HNRPNPH1
Synonym: hsa_circ_000425
Host Gene: HNRPNPH1
Genomic location(hg19): chr5:179043171-179043526:-
Genomic location(hg38): chr5:179616170-179616525:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous tissue of colon; adjacent normal tissue
Cell lines:

SW480; SW620; HCT8; Lovo; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-17, miR-106b
Biological function: may act as a tumor suppressor; low expression is associated with poor differentiation and lymphatic metastasis
Molecular mechanism: unknown (no mechanism tested in this study; discussion cites prior report of miRNA binding)
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Downregulation is associated with differentiation and lymphatic metastasis; potential diagnostic biomarker with AUC 0.839
Description:

hsa_circ_000425 (hsa_circ_0001563) is significantly down-regulated in colorectal cancer tissues and several CRC cell lines. Lower expression is associated with poor differentiation and lymphatic metastasis, and it shows diagnostic potential (ROC AUC 0.839).
Confidence score:

0.6238
Other information
Title:

The Expression Pattern and Clinicopathological Importance of Hsa_circ_000425 in Colorectal Cancer.

Journal: International journal of molecular and cellular medicine
Published: 2020
PubMed ID: 33688484
Study type:

combined biological and clinical study
Data availability: -
Code availability: -