circRNA basic information
circBase ID: hsa_circ_0051032
Name: hsa_circ_FBL
Synonym: circ‐FBL
Host Gene: FBL
Genomic location(hg19): chr19:40325092-40328483:-
Genomic location(hg38): chr19:39834452-39837843:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009688
MONDO name: myasthenia gravis
Disease details: myasthenia gravis
Disease DO ID:
 437
Disease MeSH ID:
 D009157
Disease NCIt ID:
 C60989
Disease ICD11 ID:
 1270100227
Disease OMIM ID:
 254200
Species: Human
Species details: Homo sapiens
Tissue specimen:

sera; muscle tissues
Cell lines:

C2C12; 293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: PAX7
Associated microRNA: miR‐133
Biological function: promotes myoblast proliferation
Molecular mechanism: ceRNA mechanism: circ-FBL absorbs miR-133 to increase PAX7 expression
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; EdU Staining; In Vivo Animal Model
Clinical significance:

-
Description:

circ-FBL (hsa_circ_0051032) is up-regulated in sera from myasthenia gravis patients. Functionally, circ-FBL promotes myoblast proliferation by acting as a ceRNA that sponges miR-133, thereby increasing PAX7 expression.
Confidence score:

0.6579
Other information
Title:

Upregulation of circ-FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR-133/PAX7.

Journal: Cell biology international
Published: 2021
PubMed ID: 34363272
Study type:

combined biological and clinical study
Data availability: All data included in the manuscript are available.
Code availability: -