circRNA basic information
circBase ID: -
Name: hsa_circ_SATB1
Synonym: circSATB1
Host Gene: SATB1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

THP-1; Kasumi; KG-1a; Kasumi-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CENPK, GABBR2, RBM47, ARID1A, UNC5D, ADAM19, LUM, SESN3, KCNIP3, CASD1, CDKN1B, AGO1, AGO3, DGCR8, EIF4A3, FUS, FXR2, MOV10, TNRC6
Associated microRNA: miR-450b-5p, miR-452-5p
Biological function: Promotes proliferation and cell cycle progression; inhibits premature cellular senescence (anti-senescence) in AML cells.
Molecular mechanism: Predicted interaction network suggests circSATB1 may bind miR-450b-5p and miR-452-5p and may interact with multiple RBPs; mechanistic causality not experimentally established.
Biological pathway or process:

cell cycle (inhibits); proliferation (inhibits); apoptosis (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Northern Blot
Clinical significance:

circSATB1 is significantly up-regulated in AML peripheral blood samples compared to matched normal controls, suggesting potential as a biomarker/therapeutic target.
Description:

circSATB1 is up-regulated in elderly AML peripheral blood samples and AML cell lines. circSATB1 knockdown inhibits proliferation, causes G0/G1 arrest, and promotes telomere-independent premature cellular senescence. Predicted networks suggest possible interactions with miR-450b-5p/miR-452-5p and several RBPs, but these mechanisms were not experimentally validated.
Confidence score:

0.728
Other information
Title:

circSATB1 Modulates Cell Senescence in Age-Related Acute Myeloid Leukemia: A Mechanistic Proposal.

Journal: Cells
Published: 2025
PubMed ID: 40801613
Study type:

combined biological and clinical study
Data availability: GSE229582
Code availability: -