circRNA basic information
circBase ID: hsa_circ_0014130
Name: hsa_circ_PIP5K1A
Synonym: circPIP5K1A
Host Gene: PIP5K1A
Genomic location(hg19): chr1:151206672-151212515:+
Genomic location(hg38): chr1:151234196-151240039:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005133
MONDO name: endometriosis
Disease details: endometriosis
Disease DO ID:
 289
Disease MeSH ID:
 D004715
Disease NCIt ID:
 C3014
Disease ICD11 ID:
 1838213761
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

eutopic endometrial specimens; ectopic endometrial specimens; normal endometrial specimens
Cell lines:

hEM15A; hESC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TMSB4X
Associated microRNA: miR-153-3p
Biological function: Promotes endometriosis cell proliferation, cell-cycle progression, migration and invasion, and inhibits apoptosis in vitro.
Molecular mechanism: Acts as a ceRNA sponge for miR-153-3p to upregulate TMSB4X, thereby activating TGF-beta signaling (via TMSB4X/TGF-beta2) to promote endometriosis progression in vitro.
Biological pathway or process:

TGF-beta/SMAD (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot
Clinical significance:

Potential clinical target / biomarker for EM detection and diagnosis.
Description:

circPIP5K1A is upregulated in endometriosis tissues and hEM15A cells. It promotes proliferation, cell-cycle progression, migration/invasion and inhibits apoptosis by sponging miR-153-3p to increase TMSB4X, which in turn activates TGF-beta signaling in vitro.
Confidence score:

0.705
Other information
Title:

Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.

Journal: Bioengineered
Published: 2021
PubMed ID: 34546850
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article or are available from the corresponding author on reasonable request.
Code availability: -