circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO1
Synonym: circFOXO1 / circRNA-FOXO1
Host Gene: FOXO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TNBC tissues; tumor tissues
Cell lines:

MDA-MB-231; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: BNIP3
Associated microRNA: miR-27a-3p
Biological function: Promotes TNBC malignant biological behavior (proliferation, migration, invasion), promotes EMT and autophagy, inhibits apoptosis, and reduces radiosensitivity (radioresistance).
Molecular mechanism: Exosomal circRNA-FOXO1 acts as a miRNA sponge/ceRNA for miR-27a-3p to regulate BNIP3, thereby promoting autophagy and radioresistance in TNBC cells.
Biological pathway or process:

autophagy (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

This study shows that CAF-derived exosomal circRNA-FOXO1 is increased after radiotherapy and promotes TNBC cell proliferation, migration/invasion, EMT and autophagy while inhibiting apoptosis. Mechanistically, circRNA-FOXO1 sponges miR-27a-3p to regulate BNIP3, resulting in enhanced autophagy and reduced radiosensitivity in TNBC.
Confidence score:

0.5634
Other information
Title:

CAFs exosomal circFOXO1 promotes TNBC autophagy and radioresistance via miR-27a-3p/BNIP3 axis.

Journal: Scientific reports
Published: 2025
PubMed ID: 40784956
Study type:

combined biological and clinical study
Data availability: The online version contains supplementary material available at 10.1038/s41598-025-13876-6; The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Code availability: -