| Expression pattern: |
UP |
| Associated gene: |
CREB1 |
| Associated microRNA: |
miR-203a-3p.1, miR-450b-3p, miR-502-5p, miR-1224-3p |
| Biological function: |
promotes CRC cell proliferation and tumor growth |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ_0079993 sponges miR-203a-3p.1 to release CREB1 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
High circ_0079993 expression was associated with metastasis, advanced stage, and reduced overall survival in CRC patients. |
| Description: |
hsa_circ_0079993 (circ_0079993), derived from POLR2J4, is up-regulated in colorectal cancer and functions as an oncogenic circRNA that promotes CRC cell proliferation and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-203a-3p.1 to relieve repression of CREB1, and anti-miR-203a-3p.1 reverses the growth inhibition caused by circ_0079993 knockdown. |
| Confidence score: |
0.7618 |