| Expression pattern: |
UP |
| Associated gene: |
CXCL3, METTL3 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Promotes NSCLC cell growth, proliferation, angiogenesis, migration, invasion, metastasis, EMT-like marker changes and tumorigenesis; inhibits apoptosis and G0/G1 arrest. |
| Molecular mechanism: |
METTL3 promotes circ_0003998 expression through m6A modification; circ_0003998 functions as a ceRNA by sponging miR-330-5p to positively regulate CXCL3 expression, thereby promoting NSCLC malignancy. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); angiogenesis (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes); m6A modification (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Tube Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); RIP (RNA Immunoprecipitation); MeRIP / MeRIP-seq; Bioinformatics Analysis |
| Clinical significance: |
circ_0003998 might be a new treatment strategy for NSCLC. |
| Description: |
circ_0003998 is up-regulated in NSCLC tissues and cells and functions as an oncogenic circRNA. METTL3 increases circ_0003998 expression through m6A modification, and circ_0003998 promotes NSCLC growth, angiogenesis, migration, invasion and tumorigenesis through the miR-330-5p/CXCL3 axis. |
| Confidence score: |
0.7946 |