| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-659-3p, miR-424-5p, miR-106a-3p |
| Biological function: |
Potential diagnostic biomarker of liver cancer; potentially involved in tumor progression through predicted circRNA-miRNA-mRNA regulatory networks. |
| Molecular mechanism: |
Predicted ceRNA mechanism in a circRNA-miRNA-mRNA interaction network involving miR-659-3p, miR-424-5p, and miR-106a-3p. |
| Biological pathway or process: |
p53 signaling (other); angiogenesis (other); cell cycle (other); ceRNA regulation (other); proliferation (other); invasion (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circIPO11 could significantly distinguish liver cancer samples, with an AUC of 0.7103, and represents a potentially valuable diagnostic biomarker. |
| Description: |
circIPO11 was significantly up-regulated in liver cancer tissues and validated by qRT-PCR. It was predicted to interact with miR-659-3p, miR-424-5p, and miR-106a-3p in a ceRNA network and showed diagnostic potential by ROC analysis. |
| Confidence score: |
0.5047 |