circRNA basic information
circBase ID: -
Name: hsa_circ_EMB
Synonym: circEMB
Host Gene: EMB
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003864
MONDO name: chronic lymphocytic leukemia/small lymphocytic lymphoma
Disease details: chronic lymphocytic leukemia / CLL
Disease DO ID:
 6354
Disease MeSH ID:
 -
Disease NCIt ID:
 C27911
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis
Clinical significance:

TTFT was correlated with levels of circEMB (P-value < 0.1) in univariate analysis
Description:

circEMB is significantly overexpressed in the t(14;19) CLL subgroup compared with healthy B cells (RT-qPCR validated). Its expression level shows association with time to first treatment in univariate analysis.
Confidence score:

0.4679
Other information
Title:

Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.

Journal: Journal of hematology & oncology
Published: 2025
PubMed ID: 40691637
Study type:

combined biological and clinical study
Data availability: E-MTAB-15004
Code availability: -