| Expression pattern: |
UP |
| Associated gene: |
androgen receptor (AR), AGO2 |
| Associated microRNA: |
miR-590-3p |
| Biological function: |
Promotes BC cell proliferation, migration and invasion, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-590-3p, thereby relieving miR-590-3p-mediated repression of AR and upregulating AR expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
FISH / smFISH; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circEFR3A expression in BC tissues is associated with poor prognosis and independently predicts worse overall survival. |
| Description: |
circEFR3A (hsa_circ_0006522), derived from EFR3A, is up-regulated in breast cancer and mainly localized in the cytoplasm. It promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-590-3p to de-repress/upregulate AR, and high circEFR3A is associated with poorer overall survival. |
| Confidence score: |
0.8757 |