| Expression pattern: |
UP |
| Associated gene: |
ANK3, MGLL |
| Associated microRNA: |
hsa-miR-370-3p |
| Biological function: |
May contribute to early-onset schizophrenia pathogenesis by mediating abnormalities in prefrontal cortex development; acts as a miRNA sponge. |
| Molecular mechanism: |
ceRNA sponge mechanism: hsa-circ-0000713 sponges hsa-miR-370-3p to alleviate inhibition of ANK3 and MGLL. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Luciferase Reporter Assay; Transfection; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
hsa-circ-0000713 expression level was significantly negatively correlated with PANSS positive symptoms and total score, suggesting potential as a specific biomarker for positive symptoms in EOS. |
| Description: |
In early-onset schizophrenia, hsa-circ-0000713 (from NFATC3) is up-regulated and acts as a ceRNA sponge for hsa-miR-370-3p, thereby relieving repression of ANK3 and MGLL. The axis shows consistent expression changes in patient blood plasma and in rat prefrontal cortex in MAM and Poly I:C models, suggesting involvement in abnormal prefrontal cortex development and EOS pathogenesis. |
| Confidence score: |
0.7289 |