| Expression pattern: |
UP |
| Associated gene: |
RBM45, SRSF9, HNRNPF |
| Associated microRNA: |
- |
| Biological function: |
Serves as a prognostic biomarker associated with colorectal adenocarcinoma progression, recurrence risk, and reduced DFS/OS. |
| Molecular mechanism: |
Mechanistic role is not experimentally validated; circ-PRMT1 variants are suggested to contain putative miRNA-binding motifs and are predicted to interact with splicing/RNA-binding proteins (RBM45, SRSF9, HNRNPF). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Overexpression is associated with recurrence and independently predicts shorter DFS and poorer OS; may distinguish colorectal adenocarcinoma from normal tissue (ROC AUC 0.73). |
| Description: |
circ-PRMT1 (circular PRMT1 transcripts) is significantly up-regulated in colorectal adenocarcinoma tissues versus paired non-cancerous tissues. High circ-PRMT1 expression is associated with higher recurrence risk and independently predicts shorter DFS and OS, supporting its use as a prognostic biomarker in colorectal adenocarcinoma. |
| Confidence score: |
0.6201 |