| Expression pattern: |
UP |
| Associated gene: |
WNT5A, CD34 |
| Associated microRNA: |
miR-876-3p |
| Biological function: |
promotes viability, proliferation, migration, invasion, angiogenesis, and EMT; inhibits apoptosis |
| Molecular mechanism: |
circLNPEP acts as a sponge for miR-876-3p to derepress WNT5A expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
High level of circLNPEP was associated with advanced tumor stage, advanced FIGO stage, larger residual tumor, and lower overall survival and progression-free survival. |
| Description: |
circLNPEP is up-regulated in ovarian cancer and mainly localized in the cytoplasm. It functions as a ceRNA by sponging miR-876-3p to increase WNT5A, thereby promoting proliferation, migration/invasion, EMT and angiogenesis and inhibiting apoptosis. High circLNPEP expression is associated with advanced clinicopathological features and poorer OS/PFS. |
| Confidence score: |
0.8596 |