| Expression pattern: |
UP |
| Associated gene: |
CARM1, Ago2 |
| Associated microRNA: |
miR-1243 |
| Biological function: |
facilitates HG-induced hRMEC proliferation, migration, invasion, angiogenesis and inflammation |
| Molecular mechanism: |
ceRNA mechanism: circZNF532 sponges miR-1243 to indirectly up-regulate CARM1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Tube Formation Assay; ELISA; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circZNF532 might be a potential biomarker for DR treatment |
| Description: |
circZNF532 is up-regulated in DR patient serum and in HG-stimulated hRMECs. It promotes endothelial dysfunction (proliferation, migration/invasion, tube formation, and inflammatory cytokine release) by acting as a ceRNA that sponges miR-1243 and thereby up-regulates CARM1. |
| Confidence score: |
0.7591 |