| Expression pattern: |
UP |
| Associated gene: |
PGAM1, TGF-beta, BMP4, ICAM1, VCAM1, Ago2 |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
Promotes LUAD cell viability, colony formation, proliferation, migration, invasion, metastasis, glycolysis, and xenograft tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circDUS2L functions as a miR-590-5p sponge to upregulate PGAM1 expression and activate the TGF-beta signaling pathway. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); TGF-beta/SMAD (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circDUS2L might be a promising target for LUAD treatment. |
| Description: |
circDUS2L is upregulated in LUAD tissues and cells and promotes malignant phenotypes, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-590-5p sponge to increase PGAM1 expression and activate TGF-beta signaling, suggesting potential therapeutic relevance in LUAD. |
| Confidence score: |
0.8635 |