circRNA basic information
circBase ID: hsa_circ_0090049
Name: hsa_circ_MBTPS2
Synonym: -
Host Gene: MBTPS2
Genomic location(hg19): chrX:21869626-21871621:+
Genomic location(hg38): chrX:21851508-21853503:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC xenograft tumour tissues
Cell lines:

SMMC7721; Huh7; LO2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SMARCD1, CBX1, HCFC1, RBM12B, RCC2, NUP205, ECT2, PRIM2, RBM28, COPS7B, PRRC2A, GPR107, ANKRD52, TUBA1B, ATXN7L3, FUS, MCM8, RACGAP1
Associated microRNA: miR-605, miR-548c-3p, miR-223, miR-665
Biological function: promotes proliferation; promotes G1 phase cell-cycle distribution; promotes migration; inhibits NC-induced apoptosis
Molecular mechanism: Predicted to act as a miRNA sponge and involved in a circRNA-miRNA-mRNA regulatory network (computational prediction).
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other); p53 signaling (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; In Vivo Animal Model
Clinical significance:

-
Description:

hsa_circ_0090049 is upregulated in HCC cells versus normal hepatocytes and promotes malignant phenotypes, including proliferation, G1-phase cell-cycle progression, and migration, while inhibiting NC-induced apoptosis. It was validated as differentially expressed in NC-treated vs untreated HCC xenograft tumors and is predicted to act within a circRNA-miRNA-mRNA (ceRNA-like) network.
Confidence score:

0.6111
Other information
Title:

High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma.

Journal: Cell death & disease
Published: 2019
PubMed ID: 31506425
Study type:

combined biological and clinical study
Data availability: 10.1038/s41419-019-1890-9 (Supplementary Information)
Code availability: -