| Expression pattern: |
UP |
| Associated gene: |
IFIT1 |
| Associated microRNA: |
hsa-miR-445-5p |
| Biological function: |
diagnostic biomarker for AIS; potentially involved in post-stroke immune response/neuroinflammation |
| Molecular mechanism: |
predicted ceRNA mechanism by sequestering hsa-miR-445-5p to modulate IFIT1 |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circulating circOXCT1 is upregulated in AIS and shows diagnostic value (ROC AUC 0.837) to distinguish AIS patients from healthy controls; logistic regression shows association with AIS diagnosis. |
| Description: |
circOXCT1 (hsa_circ_0129074) is upregulated in AIS patient plasma and shows diagnostic potential by ROC/logistic regression. It is predicted to function as a ceRNA by sequestering hsa-miR-445-5p to affect IFIT1, linking it to immune/inflammatory responses in AIS. |
| Confidence score: |
0.5849 |