circRNA basic information
circBase ID: hsa_circ_0079662
Name: hsa_circ_HOXA9
Synonym: -
Host Gene: HOXA9
Genomic location(hg19): chr7:27202056-27205149:-
Genomic location(hg38): chr7:27162437-27165530:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood samples; colon cancer tissues
Cell lines:

HT29; HCT116; HCT8; HT29-LOHP; HCT116-LOHP; HCT8-LOHP
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HOXA9, TRIP6, Vcam-1, VEGFC, MMP3, MMP9, MMP14, TNF-alpha, IL-1, IL-6
Associated microRNA: hsa-miR-324-5p
Biological function: Promotes oxaliplatin resistance and facilitates CRC cell growth, migration and invasion; knockdown inhibits these phenotypes in vitro and in vivo.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for hsa-miR-324-5p to regulate HOXA9, promoting TNF-alpha pathway-associated cytokine changes linked to oxaliplatin resistance.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); inflammation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Co-IP; ELISA; Transfection; Transwell Assay; In Vivo Animal Model; BrdU; Flow Cytometry（Non-apoptosis/cycle）; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0079662 is up-regulated in oxaliplatin-resistant CRC cell lines and promotes malignant phenotypes (growth, migration, invasion) and drug resistance. Mechanistically, it functions as a ceRNA sponging hsa-miR-324-5p to de-repress HOXA9, and is linked to increased inflammatory cytokines including TNF-alpha, supporting a TNF-alpha pathway-associated resistance mechanism.
Confidence score:

0.6583
Other information
Title:

Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF-alpha pathway in human colon cancer.

Journal: Journal of cellular and molecular medicine
Published: 2020
PubMed ID: 32243061
Study type:

biological research
Data availability: Data can be obtained from the corresponding author on request.
Code availability: -