circRNA basic information
circBase ID: hsa_circ_0079593
Name: hsa_circ_IGF2BP3
Synonym: circ_0079593
Host Gene: IGF2BP3
Genomic location(hg19): chr7:23381682-23383472:-
Genomic location(hg38): chr7:23342063-23343853:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005105
MONDO name: melanoma
Disease details: melanoma
Disease DO ID:
 1909
Disease MeSH ID:
 D008545
Disease NCIt ID:
 C3224
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

NHEM; A375; LM-16; LM-36
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MCAM, CHAF1B
Associated microRNA: miR-516b-5p
Biological function: Promotes migration of metastatic melanoma cells and increases aggressiveness; circ_0079593 silencing reduces tumor cell migration.
Molecular mechanism: Acts as a miRNA sponge for miR-516b-5p, thereby relieving repression of MCAM and CHAF1B.
Biological pathway or process:

migration (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0079593 is up-regulated in melanoma metastatic cell lines and promotes metastatic melanoma cell migration. Mechanistically, it sponges miR-516b-5p, reducing miR-516b-5p activity and thereby supporting higher MCAM and CHAF1B expression.
Confidence score:

0.6263
Other information
Title:

New Axes of Interaction in Circ_0079593/miR-516b-5p Network in Melanoma Metastasis Cell Lines.

Journal: Genes
Published: 2024
PubMed ID: 39766913
Study type:

biological research
Data availability: Data are contained within the article and Supplementary Materials.
Code availability: -