circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circRNA itchy E3 ubiquitin protein ligase / circ-ITCH
Host Gene: ITCH
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002492
MONDO name: acute kidney injury
Disease details: sepsis-induced acute kidney injury
Disease DO ID:
 3021
Disease MeSH ID:
 D058186
Disease NCIt ID:
 C26808
Disease ICD11 ID:
 476391827
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

kidney tissues
Cell lines:

HK-2
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: ABCA1
Associated microRNA: miR-214-3p
Biological function: protects renal function by reducing apoptosis, oxidative stress, inflammation, and mitochondrial dysfunction in sepsis-induced AKI
Molecular mechanism: ceRNA mechanism: circ-ITCH sponges miR-214-3p to upregulate ABCA1, alleviating oxidative stress and mitochondrial dysfunction
Biological pathway or process:

mitochondrial function (inhibits); oxidative phosphorylation (other); apoptosis (inhibits); inflammation (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot; TUNEL; In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

circ-ITCH is downregulated in LPS-induced sepsis-AKI models and its overexpression alleviates kidney injury by reducing apoptosis, oxidative stress, inflammation, and mitochondrial dysfunction. Mechanistically, circ-ITCH sponges miR-214-3p to relieve repression of ABCA1, forming a circ-ITCH/miR-214-3p/ABCA1 regulatory axis.
Confidence score:

0.5709
Other information
Title:

CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis.

Journal: Renal failure
Published: 2023
PubMed ID: 37782276
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Code availability: -