| Expression pattern: |
DN |
| Associated gene: |
SOCS1, Ago2 |
| Associated microRNA: |
miR-147b |
| Biological function: |
Inhibits PDAC cell proliferation, invasion and EMT (tumor suppressor role). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-147b to regulate SOCS1 expression (ceRNA-like mechanism), thereby suppressing PDAC progression. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Microarray |
| Clinical significance: |
Low circTMEM59 expression was correlated with short survival time and poor clinicopathological characteristics in PDAC patients. |
| Description: |
circTMEM59 is down-regulated in PDAC tissues/cell lines and functions as a tumor suppressor. It sponges miR-147b to relieve repression of SOCS1, thereby inhibiting PDAC cell proliferation, invasion and EMT, and low circTMEM59 associates with worse survival. |
| Confidence score: |
0.814 |