| Expression pattern: |
UP |
| Associated gene: |
TMED3, CDK6, MMP2, N-cad, Snail, Bax, cleaved caspase 3, E-cad, Ki-67 |
| Associated microRNA: |
miR-1178-3p |
| Biological function: |
Circ_0108942 promotes breast cancer cell proliferation, migration, invasion, angiogenic tube formation and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0108942 acts as a miR-1178-3p sponge to regulate and upregulate TMED3 expression, thereby promoting breast cancer progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); angiogenesis (promotes); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
Circ_0108942 may provide a new target for diagnosis and prognosis of breast cancer. |
| Description: |
Circ_0108942 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer progression by sponging miR-1178-3p and upregulating TMED3, enhancing proliferation, migration, invasion, angiogenic tube formation and tumor growth while suppressing apoptosis. The study suggests circ_0108942 may be a potential diagnostic, prognostic or therapeutic target for breast cancer. |
| Confidence score: |
0.8005 |